Da-Yuan Chen, Devin Kenney, Chue Vin Chin, Alexander H. Tavares, Nazimuddin Khan, Hasahn L. Conway, GuanQun Liu, Manish C. Choudhary, Hans P. Gertje, Aoife K. O’Connell, Darrell N. Kotton, Alexandra Herrmann, View ORCID ProfileArmin Ensser, John H. Connor, Markus Bosmann, Jonathan Z. Li, Michaela U. Gack, Susan C. Baker, Robert N. Kirchdoerfer, Yachana Kataria, Nicholas A. Crossland, Florian Douam, Mohsan Saeed
doi: https://doi.org/10.1101/2022.10.13.512134
This article is a preprint and has not been certified by peer review.(link to article)
Abstract
The recently identified, globally predominant SARS-CoV-2 Omicron variant (BA.1) is highly transmissible, even in fully vaccinated individuals, and causes attenuated disease compared with other major viral variants recognized to date1–7. The Omicron spike (S) protein, with an unusually large number of mutations, is considered the major driver of these phenotypes3,8. We generated chimeric recombinant SARS-CoV-2 encoding the S gene of Omicron in the backbone of an ancestral SARS-CoV-2 isolate and compared this virus with the naturally circulating Omicron variant. The Omicron S-bearing virus robustly escapes vaccine-induced humoral immunity, mainly due to mutations in the receptor-binding motif (RBM), yet unlike naturally occurring Omicron, efficiently replicates in cell lines and primary-like distal lung cells. * In K18-hACE2 mice, while Omicron causes mild, non-fatal infection, the Omicron S-carrying virus inflicts severe disease with a mortality rate of 80%. This indicates that while the vaccine escape of Omicron is defined by mutations in S, major determinants of viral pathogenicity reside outside of S.
Competing Interest Statement
The authors have declared no competing interest.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Note from Rob: That is literally what the fuck ”Gain of Function” research is. you are engineering this god damn thing to evade your god damn fucking vaccines and ENHANCE it to “efficiently replicates in cell lines and primary-like distal lung cells” ”unlike naturally occurring Omicron.”
So ”omnicron” has a 99% survival rate, right? these guys have their hands on a strain with a 100% fataility rate and they’re saying nooo we made it LESS lethal! Instead of being 99.8% survivable, we’re making one that escapes vaccines and “ ” ONLY ” ” kills 80% of anything it touches! Seeeeee, its ”SAFER!”
Every single one of them belongs in prison.
With everyone funding their grants.
And everyone supervising their work
NOW.
“Fuck your code of silence” and ”fuck your copyright,” this is defacto evidence of a war crime. Bush invaded Iraq, killed a million people, and then put a rope around Saddam Hussein’s neck and yanked on it , until dead , for less than what you are doing over there on American soil.
> Omicron causes mild, non-fatal infection
> the Omicron S-carrying virus inflicts severe disease with a mortality rate of 80%. <<<<— the one they just CREATED
but noooo it’s not gain of function!
”we made it safer!!!!!”
Awful lot of CHINESE NAMES ON THIS, ”Asia Times” https://archive.is/5qXHW
YSK: Bush and Cheney killed approx 150,000-160,000 Iraqi troops on their way home from an exercise after promising and assuring them safe passage. They just said ”kill them” for no reason at all.
All under the pretext of non existent ”WMDs.”
Never mind that, it was just an excuse to engage the United States in Israel’s affairs in the M.E.
Here is an actual WMD lab engineering a highly lethal virus intentionally designed to escape the vaccines they wanted to give 100% of the population.
Where’s the media, Ann Fleischli?
Where are CNN and their cameras? Do they have a conficting appointment humiliating Roger Stone or some underage child today? Do they have friends, families, or co-workers of an otherwise ”innocent until proven guilty” suspect to defame, “roll cameras on their porches” or otherwise threaten to publicly humiliate if they don’t give “voluntary” statements to the FBI?
Is Don Lemon busy taping a new cooking show and perfecting a recipe for Packed Fudge Brownies in front of those cameras Ann said CNN would come rescue us with?
Where’s Muh “Red Line” in the Sand with manufacturing bioweapons and/or WMDs?
‘Murrrrrrrica, fuck yeah.
Yesterday the government denied funding it or knowing about it and claimed Boston University did this of their own accord, with their own money.
cue me rolling on the god damn floor laughing at the notion of university researchers doing anything with “their own money,” if there isn’t a grant from someome they won’t touch it.
Yesterday’s spin was ”Boston University calls Daily Mail report on COVID-19 research ‘false, inaccurate’”
Archive link: https://archive.is/ZfnIL
Today, there is updated spin, and I am paraphrasing loosely here: “ohhh yeah, so about that, the United States government did partly fund it, I guess.”
Archive link: https://archive.is/0AHEb
